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Come on, Josh Dubnau, Ph.D, there has to be more to this story than simply measuring the strength and plasticity in these little creatures synapses and their connections, which everyone knows play a vital role in both memory formation and learning.
By selecting LTM mutants with dunce-like responsiveness in the optomotor maze, we attempted to uncover overlapping systems in the brain relevant to both memory formation and attention.
Thus, both memory formation and decay are strongest for the current context.
The finding that both memory formation and decay are greatest for the current context may seem paradoxical.
Experimental evidence from genetic and physiological studies has demonstrated the importance of CA1 for both memory formation and retrieval (Riedel et al., 1999; Dupret et al., 2010; Goshen et al., 2011).
The consistency of this finding with previous reports that showed that CA1 is involved in both memory formation and retrieval (Riedel et al., 1999; Goshen et al., 2011) further validates our methodology of using TetTag mice for population neuronal activity study in the hippocampus.
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Because the above result cannot be reproduced by existing models (orange trace in Figure 2D), we developed a new model that included context-dependent terms for both memory formation (bn) and decay (an): (Equation 2) z n + 1 = a n ⊙ z n + b n e n.
Fmr1 KO mice show deficits in both procedural memory formation and avoidance discrimination and both deficits can be rescued with Fenobam.
We recently developed the Erasmus Ladder, which allows us to test, without any invasive approaches, simultaneously, both procedural memory formation and avoidance behavior during unperturbed and perturbed locomotion in mice.
While Fmr1 KO mice improved both their procedural memory formation and avoidance discrimination after administration of Fenobam, WT mice showed a clear negative side effect in that their procedural memory formation was severely impaired.
Apparently, chronic stress produces pathological alterations on the molecular and morphological levels in the hippocampus that is involved in the regulation of both the spatial memory formation and emotional behaviors.
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both habit formation and
both route formation and
both mesophase formation and
both ocean formation and
both memory consumption and
both memory capacity and
both memory load and
both memory function and
both memory space and
both island formation and
both void formation and
both memory consolidation and
both memory demand and
both colony formation and
both particulate formation and
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