Sentence examples for both mediators of from inspiring English sources

When these 122 hits were re-run through the same database, CASP4 and UBE2M were revealed as the only essential genes that are both mediators of TNFα-induced NF-κB signaling and transcriptional targets of this pathway.

We also detected increased levels of the Smoothened receptor (1.9 fold) and the GLI2 transcription factor (2.2 fold), both mediators of Hedgehog signaling, as well as the hedgehog antagonist HIP (3.9 fold).

Furthermore, we find that the cadherins Pcdh10, which is regulated by Pou3f1 and Hoxa5, and Cdh10, which is controlled by Pou3f1, are both mediators of like-like clustering of motor neuron cell bodies.

The effects of hospital participation on overall survival in terms of natural direct and indirect hazard ratios can be summarized as follows (Table  3): The total HR of 0.58 was decomposed into a direct HR of research-activity of 0.67 (95% CI: 0.47 to 0.92) and an indirect HR for both mediators of 0.87 (95% CI: 0.75 to 0.98).

They are also involved in the pathogenesis of the disease both as mediators of inflammation and as a direct part on host tissue attack [ 4].

Our results demonstrate that p-Rb and Cyclin D1, both critical mediators of cell-cycle progression, had significantly decreased expression in both cell lines when treated with BV.

Thus, although ActRIIA and BMPRII are both essential mediators of the chemotactic response of WEHI 274.1 cells to BMP7, at the non-physiological concentration achieved by transient over expression either receptor is capable of sustaining the response alone.

The surgical resection of a solid tumour induces tissue ischaemia and acidosis, both potent mediators of gene expression.

Further, PINCH functions in the integrin and growth factor signalling pathways, both important mediators of the tumour-stromal interaction.

Exosomes may be used both as mediators of tumour resistance and as vessels for targeted drug delivery.

Further studies that address the role of T cells both as mediators of protection and modulators of immunopathology are therefore urgently required.