Women with this syndrome manifest insulin resistance by androgen excess, as well as by abnormalities of carbohydrate metabolism; both abnormalities may respond to treatment with metformin or thiazolidinediones.
There is evidence suggesting that both of these mechanisms may respond to nutrient deprivation or stress, in which relief of TPE contributes to the upregulation of a variety of subtelomeric genes (reviewed in [ 25]).
Results from five separate experiments shed new light on how humans from varying socio-economic backgrounds may respond to both natural and man-made disasters, including economic recessions, political instability, earthquakes and hurricanes.
Both domestic and wild animals may respond to predators with adaptive behaviors such as increased vigilance [8] [10], grouping and changes in group sizes [11] [13], changes in habitat selection [5], [7], and various changes in movement patterns [14] [17].
With both of these types, patients may respond to oral drugs early in the disease course, but over time fail to respond to these drugs and symptoms worsen [ 42- 44].
Changes in endogenous gene expression were extensive and partially overlapping with those of LCY-e silenced tubers: CrtISO, LCY-b and ZEP were induced in both cases, indicating that they may respond to the balance between individual carotenoid species.
There is also preliminary evidence from two studies to suggest that patients refractory to both platinum and 3-weekly paclitaxel may respond to weekly administration (Belinson et al, 2000; Kaern et al, 2001).
Interestingly, pepD and Rv2744c are both regulated by SigE, suggesting these proteins may respond to similar stresses [39].
Fish may respond to different social situations with changes in both physiology and behaviour.
