In general, both the PB and BM environments in MM patients generally inhibit DC maturation and function via cytokines and other immunologically active substances.
Both systems share some actions: BDNF is involved in the maturation and function of 5-HT neurons.
Furthermore, we have investigated the effect of three previously described HIF-1α inhibitors (chetomin [CTM], digoxin and an inhibitor of both, NFκB and HIF-1α signaling, YC-1 on MoDC maturation and function.
Both NPC proteins are also essential for proper macrophage and lymphocyte maturation and function (11, 21– 23), but whether defects in immune cells relate to the pathogenesis of NPC disease is unclear.
We evaluated whether extrinsic or intrinsic factors were responsible for the impaired maturation and function of NK cells in aging and whether impaired maturation correlated with functional hyporesponsiveness.
Estrogen, any of a group of hormones that primarily influence the female reproductive tract in its development, maturation, and function.
Other recent work shows that gut microbes control the maturation and function of microglia, the immune cells that eliminate unwanted synapses in the brain; it is, therefore, tempting to speculate that age-related changes to gut microbe composition might regulate myelination and synaptic pruning in adolescence and could, therefore, contribute to cognitive development.
Alveolar macrophages of GM-CSF-deficient mice show abnormalities in morphology, maturation, and function, depending on transcription factor PU.1 [26, 26].
These new mOP cells should significantly benefit in vitro and in vivo studies on OP maturation and function.
Our work provides a unique resource to study human-specific regulators of islet cell maturation and function.
