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Teriparatide caused significant dose-dependent increases in both markers of bone formation and resorption.
Procollagen type I N-terminal propeptide (P1NP; marker of bone formation), C-terminal telopeptide crosslaps (CTX-1) and C-terminal telopeptides of type I collagen (1CTP; both markers of bone degradation) were analysed as described earlier.
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A study carried out in postmenopausal women with early breast cancer demonstrated that a 2-year treatment with exemestane significantly increased both the markers of bone resorption (CTX: 35% and NTX: 13.7%) and of bone formation (PINP 44.1% and bone-ALP 51.7%) (Lonning et al 2005).
Two studies did not fully report on all outcomes that were measured (14, 15), which, for both studies, centered on markers of bone health that were not detailed, despite being stated as measured in the study design and methodology.
mRNA corresponding to ALP and OCN, both commonly used as markers of bone formation, and the non-collagenous protein OPN were significantly elevated in the OA group in comparison with the controls (p < 0.002, p < 0.0001, and p < 0.05, respectively; Figure 3a c).
****P < 0.0001 *** P < 0.001 Plasma calcium and phosphate were normal in both groups (Table 2), and markers of bone formation – osteocalcin and bone specific ALP – did not vary significantly.
Both BS and fluoride PET are indirect markers of bone metastatic growth, and signal is directly proportional to the formation of new bone.
In both treatment strategies, patients had a significant decrease in markers of bone turnover.
We found that HRT reduced markers of both bone and cartilage metabolism and that the decrease in markers of bone turnover was associated with BMD gain.
In both preclinical rat studies and a small clinical study measuring serum markers of bone remodeling in 14 postmenopausal women using statins, a relative decrease was found in markers of bone resorption, but there was no change in markers of bone formation [ 13, 52].
Alterations in markers of bone turnover or of calcium homeostasy were observed with both antiretroviral strategies.
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