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Adipocytes isolated from cachectic mice bearing the MAC 16 tumour showed over a 3-fold increase in lipolytic response to both low concentrations of isoprenaline and a tumour-derived lipid mobilizing factor (LMF).
The rescue of both phase pattern changes and NICD levels elicited by exposure to both low concentrations of LY411575 together with Roscovitine, DRB or XAV939 provides compelling evidence that increased half-life and higher levels of NICD brought about by these inhibitors underlies the delay to clock gene oscillations.
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Dense granule secretion, however, was maintained at both high and low concentrations of agonist.
MtΔP27 showed much higher sensitivity to both high and low concentrations of ethidium bromide than the wild type strain.
This effect was confirmed by the finding of increasing levels of FAS receptor after treatment with both high and low concentrations of E. officinalis extracts.
Again, the results showed that the signal intensities of longer probes (i.e., 23- to 25-mer) were saturated in both high and low concentrations of target oligodeoxyribonucleotide.
New strategies should be therefore developed for measuring both high and low concentrations of different protein biomarkers in the same sample in the presence of thousands of other serum proteins, usually occurring at much higher concentrations.
In the case at hand, PII bound to its receptor NRII equally well at both high and low concentrations of α-ketoglutarate, but its ability to regulate receptor activities at high concentrations of α-ketoglutarate was weakened.
Monomeric sugars are fermented using microorganisms that primarily produce ethanol, so both high and low concentrations of sugar and ethanol must be monitored over the course of fermentation in order to ensure that the fermentation is proceeding optimally.
However, both high and low concentrations of steroid induce virtually identical morphological changes in dying cells and similar changes can be induced in cells killed by deliberate feed exhaustion.
Both these groups had low concentrations of cortisol, which was not expected since "starving" ruminants should maintain the gluconeogenesis with elevated levels of glucocorticoids [ 4].
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