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Hence, the ORs produced by GWAS are unlikely to represent the true effect sizes of the functional variant(s) which are only approximated, in both location and effect, by the tagSNPs genotyped in GWAS [4], [89].
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Box and Meyer [1986. Dispersion effects from fractional designs. Technometrics 28(19 27]–27] were the first to consider identifying both location and dispersion effects from unreplicated two-level fractional factorial designs.
At 4 hr, IL-6 was significantly increased with the high-dose coarse samples from both locations, and this effect persisted at 18 hr for the FR-sample (data not shown).
The shared-map hypothesis (iii above) predicts main effects of both location and switching; there should be a beneficial effect on RTs when the locus of perceptual attention matches the old or the new location of the to-be-updated object, and this effect should be additive with the object switch effect.
With large family sizes, both LS-pool and ML-pool provided similar power and estimates of QTL location and effect as selective genotyping.
They also provide separate estimates of QTL location and effect.
The location and effect of all metabolic QTLs identified from the CIM model are presented.
Syndromes are defined by symptom location and effect of mechanical loading.
We used BEDTools and VarClassifier (Li and Stockwell 2010) to determine location and effect of each variant.
Additional file 4: A summary of the location and effect size of significant QTLs for foraging- and sleep-related traits.
113 By genetic architecture we mean quantifying the number, location, and effect sizes of genes contributing to adaptive divergence.
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