The remaining 26 patients (41%) showed both local and distant localizations.
In the case of cancer, this includes both local and distant tissue ecologies.
CRM positivity conveys a great risk of both local and distant failure, being the relevant clinical endpoints.
Finally, we highlight the need to fully consider the design of future trials in the context of both local and distant disease control, given the radiosensitizing potential and systemic activity of gemcitabine.
Stressor or exposure to stress hormone enhances the production of MMPs, which is required for both local and distant tumor spread (Sood et al. 2006; Yang et al. 2006) as illustrated in ovarian cancer cells treated with stress-levels of NE (Sood et al. 2006).
Overall, this proof-of-concept study is quite unique as it has coupled PSMA-based SPECT/CT images to the growth of DPC-1 prostatic tumors and metastases both local and distant, then histopathologically confirmed and showed to express the targeted PSMA/antigen in a time-wise manner resembling the natural history of prostate cancer.
Several electrophysiological studies in patients undergoing DBS for movement disorders have revealed evidence for disease-specific oscillatory patterns of neuronal basal ganglia activity that may act as a noisy disruptive signal disturbing both local and distant neuronal network functioning causing characteristic movement disorders.
A comparison of the physical positions of the genes and the phylogenetic analysis revealed both local and distant duplications of the LK genes.
Some miRNAs had both local and distant eQTL.
CRM positivity carries a great risk of both local and distant recurrence.
All of the other patients were disease-free (both local and distant) at last followup.
