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Notably, increased IL23R expression was observed on CD4+ T cells of patients with both limited and diffuse cutaneous SSc, including patients with ldSSc.
SSc-PAH included patients with both limited and diffuse SSc-PAH.
While the US and French cohorts individually found contrasting SSc subtype associations with rs10865710, the combined analysis showed association with both limited and diffuse SSc subtypes.
When thinking about the pathogenesis of SSc, it has becoming increasingly clear that combining both limited and diffuse forms together may obscure important associations - the clinical manifestations, autoantibody profile and natural history are quite different between the two subtypes.
HLA associations with both limited and diffuse forms of SSc largely mirrored the findings in the disease group as a whole, except in black patients with limited disease whose numbers were small (n = 54) (supplementary tables 3a and 4a by logistic regression and supplementary tables 3, 4 and 5 by χ).
A second unreported and potentially 'protective' haplotype in white subjects, HLA- DRB1*1501, DQA1*0102, DQB1*0602, was significantly decreased in a recessive model in Caucasian subjects with SSc overall and in both limited and diffuse subgroups, as well as in those patients with ACA.
Similar(54)
Our results showing that CD109 protein levels are elevated in both limited SSc and diffuse SSc skin tissue and cultured fibroblasts compared with controls suggest that upregulation of CD109 in these SSc subtypes may involve a common pathophysiological mechanism.
Gastrointestinal involvement is common in both forms of limited and diffuse SSc.
Elevated CD109 protein levels were observed in the skin tissue and fibroblasts from patients with both limited SSc and diffuse SSc, suggesting that increased CD109 protein expression might be a general feature of SSc.
Although this effect was seen both in patients with limited and diffuse cutaneous SS, only the reduction in patients with diffuse cutanous SSc was statistically significant.
These associations did not discriminate between limited and diffuse SSc.
More suggestions(17)
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both limited and unexceptional
both specular and diffuse
both limited and effective
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