Sentence examples for both lethal and tissue-specific from inspiring English sources

The present study extends these findings by showing that AOX can overcome both lethal and tissue-specific effects of various types of COX deficiency, notably those affecting early development, muscle differentiation and function and the functional maintenance of the nervous system during adult life (Table  2).

Whether Vps34 inhibitors have potential for use in immune-mediated diseases remains to be explored: germ-line loss of Vps34 is embryonically lethal, and tissue specific deletion found a critical role for Vps34 in normal neuron, heart and liver function [ 78].

Therefore, FoxN1 exhibits both temporal and tissue-specific activity.

It may also prove useful for both general and tissue-specific models of human metabolism.

Microtubule-related proteins are both species- and tissue-specific.

These markers are both cell- and tissue-specific and malleable [ 34].

Now, the metabolic stability of dissipative and stabilizing networks will be both species-specific and tissue-specific.

Mice that are null for Gsα are embryonic lethal, whereas heterozygotes show different metabolic and tissue-specific phenotypes according to parent of origin of the mutation.

However, since these mice are embryonic lethal, a tissue-specific knockout of PP2Acα in fibroblasts would provide key insights into the role of PP2A in fibrosis.

A number of different Gal4 driver lines were then tested: the use of strong/ubiquitous drivers was lethal whereas tissue-specific drivers only promoted marginal nub-RD over-expression.

TNF Receptor Associated Factor-2 (TRAF2) is one of those molecules which its role is controversial and not well defined yet 4. Since TRAF2 knock-out mice are lethal at birth, we have established various conditional and tissue specific TRAF2 knock-out to study the role of TRAF2 in different tissues.