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Arterial phase perfusion of both kidneys was reduced.
At postmortem examination, the kidneys were reduced in size with evidence of cortical attenuation.
Also, the morphological damage in the liver and kidneys was reduced and the tissues appeared like those of controls.
Importantly, reduced renal Dnase1 activity manifests itself at the same time fragmentation of chromatin in kidneys is reduced.
Pin 1 activity in obstructed kidneys was reduced to the same level as in unobstructed kidneys treated with juglone.
It has been shown that injury to diabetic kidneys is reduced in transgenic mice that over express superoxide dismutase (SOD1) [ 13].
Particularly, the production of TGF- β1 in UUO-induced Chop −/− kidneys was reduced by 1.5-fold as compared with that of WT mice.
Bikunin transcripts in the liver and head kidney were reduced by both stressors.
Metallothionein levels in liver, intestine and muscle decreased and pathological changes of kidney were reduced by MMT addition.
There would only be a problem if the spare functional capacity of the kidney were reduced, such as may be found in people (or animals) with low birth weight and a reduced complement of nephrons [ 19, 20, 25].
The concentration of total carnitine in plasma, heart, liver, muscle, and kidney was reduced in all experimental groups (P < 0.001), regardless of level of supplementation or length of feeding.
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