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The average of three measurements for each Doppler parameter of interlobar arteries in both kidneys was calculated.
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The absorbed dose to the kidneys was calculated both with the spherical S-values and with the nephron model by Hobbs et al. [21].
Fraction retained in the kidneys was calculated using the equation: Cl r – Cl u / Cl r.
For all scintigraphies, mean renogram curves were analyzed and the "fractional uptake rate" (FUR; %I.D./min ± SEM) of the tracer by the kidneys was calculated as an index of renal clearance.
The fraction of the tracer retained in the kidneys was calculated as the relative difference in renal clearance (Clr-tracer) and urinary clearance (Clu-tracer) as a fraction of the renal clearance (Clr-tracer).
Only the self-absorption dose from activity uptake in the kidneys was calculated.
The differentiation efficiency of MGV to detect pathological changes in the kidneys was calculated for dogs and cats.
Renal blood flow in the left and right kidneys was calculated using a reference blood sample as previously described in detail, [ 33] and is expressed as the mean renal blood flow.
For control kidneys, the AUC ratio between individual kidneys and the average of bilateral kidneys were calculated.
Washout [WO) in the left kidney was calculated from 15 min and 4 h images using skeletal muscle as a reference. A secondary analysis was focused on the SPECT-CT images.
The perfusion ratio between the IR kidney and contralateral kidney was calculated based on the assumption that the contralateral kidney had normal perfusion and could serve as a reference.
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