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Given that most human cancer is the result of both genetic and environmental risk factors, accurate assessment of both is required to develop an understanding of molecular mechanisms of carcinogenesis.
They are coexpressed in the embryo, and removal of both is required to elicit a strong phenotype.
Furthermore, decreasing soluble Aβ without affecting soluble tau levels did not improve cognition, suggesting that a reduction in both is required to rescue cognitive impairments in this mouse model [ 73].
For example, pta and eutD appear together since the deletion of both is required to eliminate the phosphate acetyltransferase activity, while either fnr or arcA appears since the deletion of either transcription factor results in a similar phenotype.
Similarly, Ezh1 and Ezh2 play redundant roles in hair follicle stem cells and a deletion of both is required to affect progenitor cell proliferation in the bulge (Ezhkova et al., 2011).
The data we have obtained with isoform-selective PDE inhibitors indicate that PDE3 and PDE4 are the principal isoforms that regulate the pertinent PKA activity, and that these PDE isoforms operate in a redundant manner, such that inhibition of both is required to achieve marked inhibition of PKD activation.
Similar(54)
Both were required to wear electronic monitoring bracelets.
Should either or both be required to trim their operations?
Both are required to save a portion of their wages.Will it make any difference?
As part of the companies' original agreement for the loans, both were required to submit restructuring plans.
Mr. Giuliani and Ms. Hanover have both been required to file net worth statements with the court, but neither has been made public.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com