These summaries are both informative and guaranteed to be robust to perturbations [18]: in particular, they do not vary under changes in coordinates or under deformations of the individual samples, which makes them parsimonious descriptions of arbitrary datasets.
Use of more than 15 kb sequences of the mitochondrial genome provided more informative and robust data than previous studies of short mitochondrial segments (e.g., control region or cytochrome b) as shown by the reliable reconstruction of divergence patterns among Hylobates gibbons.
The lack of common markers across carrot maps is mainly due to an insufficient availability of informative and robust PCR-based markers.
However, de-novo sequencing differs from re-sequencing because it requires the generation of an informative and robust sequence with a higher sequencing depth.
Among various measures of model quality, Global Distance Test Total Score (GDT_TS) is widely considered one of the most informative and robust.
Previous studies of genetic diversity suggested that SSRs are more informative and robust than other available molecular marker resources, such as amplified fragment length polymorphism (AFLP) and random amplified polymorphic DNA (RAPD) in castor bean [ 12, 13].
We take a hypothesis-free approach to identify genetically influenced NMR features and investigate whether specific ratios between NMR intensities at two chemical shifts can provide informative and robust biomarkers.
Using NMR data of plasma samples from 1,757 individuals from the KORA study together with 655,658 genetic variants, we show that ratios between NMR intensities at two chemical shift positions can provide informative and robust biomarkers.
For most purposes, however, the relative concentrations are informative and robust measures of the dynamics of the system, for instance when we are interested in fold changes over the time-course of the experiment (see Discussion below).
Therefore, more informative and robust prognostic markers are required, which also need to be compatible with small amounts of often degraded, formalin-fixed, paraffin-embedded (FFPE -derived DNA, as typically only a sparse amount oFFPE -derived available for analysis from DNAS lesions.
