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Rather than an unaccountable burst of both information and catalysis, the peptide/RNA scenario lays out a credible path to complexity.
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In this scenario, information and catalysis both began simply and evolved together.
That hypothesis is broadly held to be the only likely scenario for simultaneous introduction of genetic information and catalysis [ 15].
Among all of the biological macromolecules, the functional versatility of RNAs is unique including encoding or transferring genetic information and performing catalysis.
RNA may have acted as the central part of early cell metabolism as it can both transmit genetic information and carry out catalysis as part of ribozymes.
The results demonstrate that the AuNCs allow for H2O2 sensing based on their capacity for both fluorescence and catalysis.
Rare-conformational transitions between sub-states have biophysical relevance in both binding and catalysis, as we have demonstrated in this paper for ubiquitin and cyclophilin A respectively.
Lys80 is also near Glu11 and His243, two residues important for both autoprocessing and catalysis.
The presence of Leu20 is therefore beneficial to both thermostability and catalysis.
These results raise the interesting possibility that APC/CCdc20 substrate binding and catalytic stimulation are intrinsically coupled, such that degrons enhance both affinity and catalysis.
Thus, the same qualitative conclusion that both translocation and catalysis are rate-limiting for the elongation reaction can be drawn from this alternative approach.
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