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The combination of co-stimulatory modulation and FVAX yielded high levels of inflammatory cytokine production both in the periphery and in the tumor.
While CD4 effector infiltration and proliferation were only increased by CTLA-4 blockade (Figure 4), α4-1BB dincreasease inflammatory cytokine production from these cells both in the periphery and within the tumor itself.
Another, surprising finding was the increase in vascular diameter both in the periphery and central parts of the tumor, since HBO is generally know to induce vasoconstriction.
Our analysis included lymphocyte characterization both in the periphery and in mucosa-derived TILs, by surface markers and intracytoplasmic staining (IL-17, FoxP3, T-bet).
The available literature clearly suggests that increased circulating FFA may directly contribute to the underlying pathophysiology of type 2 diabetes, particularly, through the development of insulin resistance both in the periphery and the liver [ 32].
The anti-human CD69 treatment highly increased LSK and CLP cell proliferation and numbers, both in the periphery and in the BM, and also augmented S1P1 and CXCR4 expression.
Similar(33)
In studies by the same group using a pair of measures which isolate magnocellular (M) from parvocellular (P) sensitivity (31), migraineurs were reported to show elevated thresholds (reduced sensitivity) to both stimuli in the periphery (implicating both M and P pathways) but normal performance in the fovea (30, 32).
These results suggest that insulin receptor levels exist in a dynamic insulin-sensing equilibrium both in the brain and the periphery.
Although T cells are submitted to negative regulation both in the thymus and the periphery, dead cells are short lived in vivo due to efficient clearance mechanisms [41] [44].
Further studies found neurons specifically responding to these GLVs both at the periphery and in the AL of L. decemlineata (De Jong and Visser, 1988a, 1988b).
In DCIS, the distribution typically showed areas of increased expression both centrally and in the periphery.
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