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However, despite this effective reduction of cell numbers both in the peripheral blood, as well as at the site of infection, we did not observe an increase in susceptibility to S. pneumoniae in mice rendered lymphopenic, either directly at the time of bacterial infection (Fig. 4C) or 12 h later (Fig. 4D).
We studied T cells both in the peripheral blood (PB) and the tissue-infiltrating lymphocytes (TILs) from the mucosa of 14 CD patients at presentation and after a GFD, vs. 12 controls.
The aims of this study were to determine chemokine receptor expression by B cells both in the peripheral blood of normal donors and subjects with RA, and at the inflammatory site in RA, and the effects of chemokines on B cell activation.
Of equal importance appears to be the efficient depletion of the pathogenic, autoimmune triggered/self-reacting CD20+ cells both in the peripheral blood, as well as localized in tissues and compartments, where they directly induce inflammation and initiate autoimmune cascades, the latter being a much less studied aspect of treatment effect.
Subsequently, Jung et al. addressed CD244 as an important inhibitory molecule on HBV virus-specific CD8+ T cells by providing evidence that in chronic HBV-infected patients, these cells expressed higher levels of CD244 coincidence with an increased expression of PD-1 both in the peripheral blood and hepatic tissue compared with acute and resolved infection.
New evidence suggests that physiological alterations contributing to chronic pain states take place both in the peripheral and central nervous systems.
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Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems.
In animals, NO functions as a neurotransmitter both in the central and peripheral nervous system.
There exist differences in expression patterns both in the brain and peripheral in the different murine models, and as postulated by Newsom et al, this could be attributable to the animal model used [ 14].
Propranolol operates on noradrenergic pathways both in the central and the peripheral nervous system.
Biologically, the proportion of CXCR4+ blasts and lymphocytes both in the bone marrow and peripheral blood increased after plerixafor administration.
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