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P66Shc story suggests that necessary regulators of oxygen and energetic metabolism may be involved both in the onset of the acute phase of diseases and in the induction of aging related detrimental changes that ultimately kill the organism.
In summary, the significant higher presence of the variant allele I249 in homo- and heterozygosis found in controls (91%) and in AMI survivors (94%), with respect to the patients died of AMI (48%), showed the relevance of this polymorphism both in the onset and outcome of acute myocardial infarction, confirming the correlation between CX3CR1 genotype and prognosis of the acute event.
The significant higher presence of the variant allele I249 in homo- and heterozygosis, found in controls (91%) and in AMI survivors (94%), with respect to the patients who died of AMI (48%), showed the relevance of this polymorphism both in the onset and outcome of acute myocardial infarction.
A combination of 10-fold increased biochemical reactivity and apoptosome immobilisation further enhanced the calculated spatial heterogeneities (Fig. 6E) and resulted in considerable anisotropies both in the onset of substrate cleavage as well as in half-maximal substrate cleavage (Fig. 6F).
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In addition, the fact that expression of the disease phenotype is variable both in the age of onset and severity suggests that additional factors may be required to induce disease, such as stress and activity level [ 30].
The possibility to capture the presence of rare taxa will thus be extremely valuable in studying both the onset of coral-microbial associations and the spatio-temporal variability in coral-associated microbiota.
Needs assessment, clarifying UNICEF's role both in the aftermath of rapid-onset disasters and at the reconstruction phase.
Both scenarios largely differ in the onset of bistablity and oscillations.
The results of analytical pyrolysis assays of the polyurethane systems clearly demonstrate that low levels of POSS substitution (<10 wt. %) lead to a significant increase in both the onset temperature of thermal de-polymerization and a reduction in the yield of volatile degradation products.
Increased oxidative stress has been implicated in both the onset and the progression of diabetes mellitus and its complications.
PLK-1 (Polo-like kinase-1) is a crucial mitotic protein kinase that plays an essential role in both the onset of G2/M transition and cytokinesis.
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