These are involved both in the establishment of enhancer sites and in the subsequent looping and regulation of gene expression in cis [8 13].
In particular, regulatory proteins, like the transcription factors Sox9, Runx2, Osterix, Twist and Mef2c have distinct functions both in the establishment of the vertebral bodies and later in the differentiation and maturation of specific skeletal cell types (review [ 13]).
We have discovered an additional role for both kinases in the establishment of spindle orientation during mitotic progression.
These initiatives created the basis for the social determinants movement [ 8] and later the public health reform, which was influential, both in supporting the establishment of SUS and in ensuring that HRH elements were considered as central to that establishment.
RPTP domain structure suggests cell adhesive properties, and studies on Drosophila mutants have provided strong evidence that specific RPTPs act together to provide a set of partially redundant signals necessary for muscle targeting and fasciculation decisions in CNS neurons [ 1, 2], both crucial components in the establishment and maintenance of neural circuits.
Given the significant association of HPS and associated tumours with increasing levels of aberrant promoter methylation (CIMP), including extensive methylation in the normal mucosa, and the role of DNMTs in both the establishment and maintenance of DNA methylation in humans, we examined the potential association of genetic and epigenetic disruption of DNMTs in HPS.
Since protons are positively charged, the movement of protons across the thylakoid lamella during both light reactions results in the establishment of an electrical charge across the lamella.
Both should be interested in the establishment of a legitimate government and, for that reason, in fair elections.
In this view, both miRNAs and APA can, in principle, dramatically reshape gene expression output, implying they both play key roles in the establishment and maintenance of cell and tissue identity.
Many integrins are expressed by DCs and T cells and we investigated the role of the αM (CD11b) and β2 (CD18) integrins, i.e. CR3, expressed on both DCs and LCs, in the establishment of HIV-1 infection.
We also reveal that recombination has played an important and traceable role in both the establishment, and the maintenance, of diversity in the sequences.
