Sentence examples for both in the active from inspiring English sources

In general, GR has proven to be a flexible enzyme capable of binding a variety of small molecules both in the active site and at allosteric binding pockets, some of which have included cyclic substrate-product analogues.

A sensitivity analysis using a per protocol strategy of analysis will be performed to determine the impact of the adherence to the protocol both in the active monitoring and antidepressant groups.

Thus, the introduction of mGPS and NLR may promote an impartial clinical decision-making that will have a direct impact on patient care both in the active treatment and in the palliation setting.

It was found that tin dissolves both in the active and partly passive potential region in the form of bivalent tin.

Here, we present the crystal structure of human p38α MAP kinase, which has a lead compound bound both in the active site and in the lipid-binding site of the C-terminal cap.

In recent years, the quality of the T-cell response has been highlighted as important to the induction of memory T cells (22), and multifunctional CD4 cells expressing combinations of the cytokines IFN-γ, tumor necrosis factor alpha (TNF-α), and interleukin-2 (IL-2) have been implicated both in the active phase of the disease (23) and as correlates of vaccine-induced protection (24 – 24).

The TREX1 D18N and V201D mutants are able to bind both metals in the active site, but with inter-metal distances that are larger than optimal for catalysis.

As a consequence, if two protein kinase inhibitors both bind in the active site with similar affinity, but only one has to compete with ATP, then the competitive inhibitor at the protein-binding site will inhibit the enzyme more effectively.

There is a pronounced difference between both enzymes in the active center.

This result in a blockade of the antiparallel arrangement of both substrates in the active site and thus the parallel arrangement yielding R-product is preferred.

We assume that Rho1 exerts both activities only in the active, GTP-bound form (Rose et al., 2005).