Sentence examples for both in the activation from inspiring English sources

IDO may exhibit its immune inhibitory functions both in the activation phases (in the draining lymph node) as well as in the effector phases (at the site of the tumor).

As judged from our results with tezosentan, ET-1 seems to be involved both in the activation and production of PKC in the lungs.

In summary, recent literature has demonstrated that protein serine/threonine phosphatases have important functions both in the activation of the DDR and in its negative regulation.

Mitochondrial pathway activation results both in the activation of Caspase-3 by Caspase-9 and also relief of Caspase-3 inhibition by the protein DIABLO [ 8].

The NF- κB/Rel family of proteins are implicated both in the activation of DC, and in the cellular response to radiation (Rescigno et al, 1999; Jung and Dritschilo, 2001).

Interleukin 1 and related TLR2 pathways were highly affected, and both converged in the activation of NF-κB.

For the territorial male some genes related to synaptic plasticity show elevated expression such as gpsm1, a G-protein signaling modulator and ncs1, a neuronal calcium sensor, both involved in the activation or deactivation of the G-protein cascade.

There are two main pathways to apoptosis – the 'death receptor' (also called 'extrinsic') and the 'BCL-2-regulated' (also called 'mitochondrial'intrinsicsic' or 'stress') pathway, both culminating in the activation of caspases that effect cellular destruction.

In addition, several lines of evidence support the role of both nuclear receptors in the activation of megalin expression.

Stimulation with BCG induced >2 fold more G-CSF and GM-CSF, both cytokines involved in the activation and differentiation of monocytes into macrophages.

Ultimately, both pathways converge in the activation of caspase-3, the caspase that is the main executioner, [ 15] which has multiple targets and degrades structural and functional proteins [ 11].