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The Ser/Thr and Tyr kinases differ completely from the HKs both in sequence and structure.

They comprise the most poorly conserved family of molecular chaperones, showing high heterogeneity both in sequence and size [ 129].

The second motif is found 10-30 nts downstream of the PAS but is poorly understood due to its low conservation both in sequence and position.

According to the data available at the GeneDB database [ 14], the locus is located at chromosome 13 and contains twelve copies (LmjF.13.0280 to LmjF.13.0390) having identical ORFs both in sequence and length (1356 bp), arranged in a head-to-tail tandem organization.

In particular, the cdc6D-associated origins showed high conservation between H. hispanica and H. amylolytica (type 1), or between H. sinaiiensis and H. argentinensis (type 2); however, these two types of cdc6D-associated origins showed limited conservation both in sequence and in structure (fig. 2 B).

Two conserved putative IHF binding sites were detected in the putative ori region of E. canis and the two E. ruminantium strains, with all of them being similar both in sequence and position while a single putative IHF binding site was present in E. chaffeensis which was the only common IHF binding site found in all four Ehrlichia strains.

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The identified new architecture suggests that both in-sequence and out-of-sequence tectonometamorphic discontinuities are important components that formed the duplexing structure of the GHC in the central and eastern Himalaya, thus calling for more sophisticated numerical simulation than the current models such as the channel flow and critical taper.

The proposed hybrid method uses both PSO and SA in sequence and integrates the merits of good exploration capability of PSO and good local search properties of SA.

One was the enormous technological challenges the Human Genome Project presented, both in sequencing and mapping, but also in computation and analysis.

Our experience underscores the value of targeted methods, both in sequencing and in analytical approaches.

Among the eukaryotic pathogens whose genomes have so far been sequenced, the malaria parasite, Plasmodium falciparum (P. falciparum), posed the most technical challenges both in sequencing and assembly of the draft genome [ 1].

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