Sentence examples for both in rodent models from inspiring English sources

In contrast, exogenously administered intermittent PTH is anabolic stimulating skeletal remodeling and raising BMD both in rodent models and in human studies [ 153, 154].

[18F]FEOBV has also been successfully used to differentiate and quantify cholinergic losses associated with normal aging from those resulting from a pathological process, both in rodent models [14] and in human postmortem tissues from subjects with AD [33].

Sulindac has been shown to be efficacious both in rodent models of FAP and in human FAP patients.

For example, systems approaches have been used to capture the pathophysiological determinants of tumor drug delivery to the intended target and to successfully project the impact of elevated interstitial fluid pressure on fluid flow rates exiting the tumor, both in rodent models and in human cancers.

Experimental studies have indicated carcinogenic effects of both PFOA and PFOS in rodent models, at least at high exposures; however, no associations between these PFAA's and CRC have been reported.

Chemical chaperones such as 4-phenylbutyrate (PBA) and tauroursodeoxycholic acid (TUDCA) have been shown to reduce ER stress both in vitro and in vivo in rodent models (91).

The n-3 fatty acids also inhibit the prostaglandin synthesizing enzyme cyclooxygenase-2 (COX-2) which is up-regulated during inflammation, the expression of the pro-inflammatory cytokines tumour necrosis factor-α (TNF-α) and interleukin-1 (IL-1) and the proliferation of lymphocytes as shown both in vitro and in rodent models [ 13- 15].

Recent evidence suggests that DR improves risk factors profiles for protection against cardiovascular diseases in humans [4] and has both cardioprotective and neuroprotective actions in rodent models of ischemic diseases [27], [28].

The relationship of these abnormalities to dystonic movements is unclear, as they occur in rodent models both with and without abnormal movements.

Captopril, an angiotensin-converting enzyme (ACE) inhibitor, has both antiangiogenic and antitumour activity in rodent models (Volpert et al, 1996) and inhibits the growth of human renal carcinoma xenografts (Hii et al, 1998).

This is indeed the case; however, despite the fact that arterial smooth muscle cells express multiple isoenzymes of the GRK family (22), only GRK2 expression has been reported to be elevated in both hypertensive patients (8) and in rodent models of hypertension (9, 10).