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The human POD will be divided by various factors to produce a human RfD, although these factors will need to differ both in rationale and in numerical value from those presently applied to in vivo data.
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"It goes further than past attempts in both the rationale and in the desired implementation," he said.
Revisability is strongly related to the transparency condition because the transparency of the original decision both in terms of rationales and ultimate recommendations facilitates the identification of mistakes.
Such a platform could furthermore facilitate discussion on the implementation of reimbursement restrictions, which differ across countries in terms of both rationale and frequency of application [ 26].
Concurrent chemoradiation has both preclinical rationale and clinical efficacy in many solid tumour types.
57 In view of both this pharmacologic rationale and the low transplacental transfer of PIs (which implies low cord-to-maternal plasma ratios), an association between low birth weight and PI-based regimens seems unlikely.
And then there was Stalin, providing a built-in rationale to continue to build a fighting force.
Osgood can now see the flaw in this rationale, and she aims to expose it.
The lung cancer exercise training study: a randomized trial of aerobic training, resistance training, or both in postsurgical lung cancer patients: rationale and design.
Previous publications described in detail the rationale and methods of the studies [ 1, 15– 17].
The curve identified in the training data is sustained for the validation data as well: they both fall in line with the underlying rationale, and we are quite confident in the strength of the proposed model.
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