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There is a growing understanding that insulin resistance may mediate the relationship between chronic high-fat diets and reduced cognition, both in rat models and in humans with type 2 diabetes, while at the same time contributing to cardiovascular disease, depression and hypertension [ 35].
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In rat models, both the right and left insular cortices have shown to the have influence over autonomic function.
For example, GABAA agonists, such as muscimol and THIP (4,5,6,7-tetrahydroisoxazolo[5,4 c]pyridin-3-ol hydrochloride), have been shown to alleviate both thermal and mechanical hyperalgesia in rat models of painful neuropathy after peripheral nerve injury, whereas application of GABAA antagonists such as bicuculline and picrotoxin led to more pronounced hyperalgesia [ 37].
Our previous studies have shown that administration of a novel vasoactive peptide adrenomedullin (AM) and its binding protein (AMBP-1) reduces the systemic inflammatory response in rat models of both hemorrhage and sepsis.
Moreover, Wnt3 is reduced in both the adult brain and pancreas in rat models of diabetes.
Inhibition of adhesion molecule expression and microglial activation has also been confirmed by Deng and colleagues in rat models of both focal cerebral ischemia and brain inflammation [ 35].
SLV338, a NEP/ECE inhibitor, abolished renal tissue damage (interstitial fibrosis, glomerulosclerosis, renal arterial remodelling) in rat models of both acute kidney failure as well as chronic renal failure.
Both testosterone and dihydrotestosterone (DHT) induced prostatic adenocarcinoma in rat models [3].
Khan, J. et al. Interleukin-10 levels in rat models of nerve damage and neuropathic pain.
Two experimental studies have shown accelerated closure of nonsplinted excisional wounds in rat models.
He and his lab members study the neurobiological mechanisms of relapse to drugs of abuse, as assessed in rat models.
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