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However, a high level of miR-146a expression was found to be cervical cancer-specific since its expression was down-regulated both in normal tissues and in HPV-infected raft tissues with pre-neoplastic lesions.
AS plays a major role in gene regulation, both in normal tissues as well as in disease.
Extensive mRNA expression data analysis from public databases (ESM Tables 4– 6) links G7e and Fignl1 to cell division, both in normal tissues and in tumours.
We investigated the methylation status of two CpG sites within the 3' region of H19 (exon 5: positions 3321 and 3324) both in normal tissues as well as in TGCTs.
The association of increased ORβ isoform expression with tamoxifen sensitivity, suggests a possible mechanistic role, and one possible mechanism may be suggested by several publications which have shown that ORβ isoforms have a modulatory effect on ORα, both in normal tissues (Weihua et al, 2000) as well as in cell culture models (Ogawa et al, 1998; Hall and Mcdonnell, 1999).
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Our findings underline the importance to specify the potential functions of AQPs beyond water transport both in normal tissue and tumor cells.
Additionally, the biodistribution of both markers in normal tissues was assessed under similar conditions.
Follistatin and FLRG were expressed both in normal tissue and in all the breast diseases investigated.
Transcripts for LH receptor were observed both in normal tissue and neoplasms.
Our results show that Fas and FasL are co-expressed both in normal tissue and in breast tumours.
In contrast to CD31, which is expressed on blood vessels both in normal tissue and in malignant lesions, endoglin is found predominantly on peritumoural and intratumoural blood vessels.
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