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The quantitative expression profiles of whole gene family both in normal mouse tissues and across the course of macrophage activation not only help to identify a functional module of CCCH zinc finger genes in the regulation of macrophage activation but also provide the framework for future studies to dissect the function of this emerging family.
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These findings indicate that WEP has laxative effects both in normal mice and in clonidine-induced constipation model mice.
In examining the chemokine receptor profile of circulating CD45+ cells cells in mice, we have found that both in normal mice and animals challenged with bleomycin, CXCR4 is the most commonly expressed surface receptor, being present in approximately 70% of the cells [ 27].
To further investigate CR1 expression and localization in the colon, we analyzed tissue sections of normal and neoplastic colon and found that CR1+ cells localized at the bottom of colonic crypts in normal mouse (both neonatal and adult, Figures 1f and g) and human colon, whereas CR1 expression was deregulated in cancer, being widely present in neoplastic tissues of either mouse and human origin.
SmoM2 tumors thus recapitulate the phenotypic and functional hetereogeneity observed in normal mouse skeletal muscle.
Similarly to other authors,16,17 we found that sympathetic nerve fibers are present in normal mouse corneas.
Instead, we identified13 more than two δ mRNAs in normal mouse spleen and in two IgD-secreting plasmacytomas14, TEPC 1017 and TEPC 1033.
Genes marked red are not expressed in normal mouse thyroid.
(D ) RBM47 expression in normal mouse lung.
Immunohistochemistry of SOX9 and OPN in normal mouse liver.
Their proportion is even smaller in normal mouse brain.
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