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Studies of the imprinted genes of mammals have demonstrated the underlying complexity of gene regulation and have helped to identify the numerous epigenetic mechanisms that we now have broad and significant roles both in normal development and in human disease.
In the nervous system, the envelopment of synapses by the neuronal cell body both in normal development and following axon injury has been described (Borke, 1982; Ronnevi, 1979) as has phagocytosis of diverse materials by neurons (Bowen et al., 2007).
EMT plays a considerable role both in normal development and diseased states.
Astrocytes play an important role in CNS function, both in normal development and following injury (Zhang and Barres, 2010).
Maintenance of oxygen levels within tight limits is essential throughout life, but is particularly important during periods of rapid cellular proliferation, both in normal development and neoplasia.
AiA provides a mechanism to explain cohort behavior of dying cells that is seen both in normal development and under pathological conditions.
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Prdm family members are known to control cell proliferation both in cancer [10] [15] and in normal development [16].
The upregulation of Msi genes in glioblastoma motivated the choice of NSCs as a system to study the molecular roles of Msi proteins, a cell type where both proteins are highly expressed in normal development, and where their target mRNAs are likely to be present.
Therefore, the roles of cyclin E may be more important for aberrant cell divisions than for divisions in normal development in both species.
In doing so, both parties set up a disingenuous conversation about what is actually involved in normal development.
In normal development of the brain, neurons and glia are generated from both NSCs and more limited INPs.
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both in normal uterine
both in healthy development
both in normal phase
both in normal skin
both in normal liver
both in normal soil
both in neuronal development
both in normal breast
both in normal tissue
both in economic development
both in early development
both in physical development
both in normal mouse
both in normal term
both in normal aging
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com