Sentence examples for both in mouse models from inspiring English sources

Further, APMV-1 has been developed as safe and effective oncolytic agent both in mouse models and also in human clinical trials [51] [53], [57] [59].

Moreover, additional studies have found a lack of correlation between gluconeogenic gene expression and hepatic glucose output both in mouse models [ 32] and in patients with T2D [ 33].

This work serves as the foundation for future experiments with LLL3 and other inhibitors of STAT3 both in mouse models of OSA with eventual application in dogs with spontaneous OSA, as a prelude to clinical work in children.

SIRT1 levels have been shown to change both in G93A mouse models as well as in patient tissue, suggesting that this protein may be a relevant disease target both in mouse models and human disease.

The second heart field plays a critical role in the development of the cardiac outflow tract, and mutations in genes expressed in the second heart field result in outflow tract defects both in mouse models and in humans.

The safety of airway delivery of these nanoparticles is well documented both in mouse models and in this clinical trial [18], [19].

In this regard, we and others demonstrated that the metalloprotease-processed CD95L actively participates in aggravating inflammation and auto-immunity both in mouse model and humans affected by systemic lupus erythematosus (SLE).

Furthermore, in both humans and in mouse models, cancers can respond to chemotherapy by a massive senescence response followed by tumour cell clearance [ 3- 5].

66 Insulin has been shown to be an important, if not the most important, antigen in both humans and in mouse models of T1D.

Since AD develops in the aging human brain, which is subject to effects of sex hormone depletion in both sexes, gonadectomy in mouse models of AD recapitulates a critical aspect of human reproductive aging in males and females.

Recently, a novel IL-17 secreting T cell subset (Th17) has been implicated in RA disease pathogenesis in both human RA and in mouse models of disease [10].