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Mounting evidence suggests that sepsis-induced morbidity and mortality are due to both immune activation and immunosuppression.
It is exemplified by a recent genomic description in trauma patients [14], showing that mRNA genes of both immune activation and immune suppression were concomitantly expressed early after injury.
Host responses to viral infection include both immune activation and programmed cell death.
There is need for further studies to determine other potential drivers of both immune activation and PD-1 expression among HIV-infected patients on successful ART.
Furthermore, there are data to support the view that chronic stress appears to result in suppression of the immune response, whereas both immune activation and suppression have been associated with acute stress.
Due to the link of kidney diseases to both immune activation and increased cardiovascular risk, the third aim was to explore these associations in diabetic patients with prevalent renal dysfunction at baseline.
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In this regard, the manifestation of lymphoma is very similar to that seen in transplant patients and those with graft versus host disease (GVHD) where both chronic immune activation and immune suppression are present.
Thus, DEM CD4 T cell expansion is associated with both innate immune activation and decline in circulating Tregs.
In the context of HIV, both controlling immune activation and generation of effective HIV-specific immune responses may need to be balanced.
Of interest, the deregulated expression of nuclear receptors was not restored under HAART and was linked to an altered expression of genes which supports both an immune activation and altered lipid metabolism in monocytes.
On the other hand, Leishmania infection can impair both the chronic immune activation and the lymphocyte depletion and can accelerate progression to AIDS, particularly in HIV-1-infected individuals [ 44, 45].
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