Both the identification and validation of the postdiagnosis samples showed significant consistent DNA hypermethylation in the cancer twin compared with the paired healthy co-twin (Wilcoxon signed rank test; P < 0.05).
This approach should represent a valuable tool for identification and validation of both luminal and membrane lysosomal proteins.
Global gene expression analysis with DNA microarray technology has proven to be a useful tool for target identification and validation in both the preclinical and clinical settings.
The identification and validation of both Gct4 and Gct6 susceptibility genes in the mouse will provide a foundation for the pursuit of genetic and epigenetic features that contribute to pediatric cases of juvenile-type GC tumors.
2. There is no citation for, "Global gene expression analysis with DNA microarray technology has proven to be a useful tool for target identification and validation in both the preclinical and clinical settings".
Djabalah also presented preliminary data showing that iPS cells provide a more stable platform for drug discovery in terms of target identification and validation for both inhibitors and drivers of differentiation.
He also used both next generation sequencing and mass spectrometry for identification and validation of mutated peptides in tumors.
In the words of chairman John Green-Armytage, who has a long record in expanding high-technology companies in electronics as well as pharmaceuticals: "ValiGen's integrated portfolio of bioinformatics, genomics and chimeraplast technologies enables the identification and validation of novel targets for both pharmaceutical and agricultural products".
From an international perspective, the OECD has formed a special subcommittee to oversee the identification and validation of internationally harmonized test guidelines to assess EDCs in both humans and wildlife (Huet 2000).
Target identification and validation will also be a key area of work.
