Sentence examples for both hypomorphic and null from inspiring English sources

The combination of both hypomorphic and null alleles in heterozygous compounds results in late embryonic lethality (E14.5 E16.5) with phenotypic features intermediate between null and hypomorphic mice.

Similarly to AGFP homozygous larvae, both hypomorphic (cactus[E8]/cactus[IIIG]) and null (cactus[E8]/cactus[D13]) mutant combinations [20] together with AGFP[23]/+ showed GFP fluorescence in aggregating hemocytes and especially in the outer border of melanotic capsules (data not shown and Figure 5G).

It is possible that a more sensitized screen using hypomorphic and null alleles might reveal a genetic interaction.

Deletion of Lrig3 from canal epithelial cells results in the same lateral canal truncation evident in hypomorphic and null alleles of Lrig3 (Fig. 4G).

To determine the in vivo function of PiT1, we generated an allelic series of PiT1 mutations in mice by combination of wild-type, hypomorphic and null PiT1 alleles expressing from 100% to 0% of PiT1.

To provide insights into the physiological role of PiT1 in mice, we established an allelic series of PiT1 mutations arising from the combination of normal, hypomorphic and null PiT1 alleles in mice.

As strong hypomorphic and null alleles of mei-P26, mei-41, Klp3A mei-352, and Cap have greatly reduced fertility or are sterile, we did not anticipate isolating strongly hypomorphic alleles of these genes.

Here, we describe a genetic screen to generate a series of ethyl methanesulfonate (EMS -induced Top2 allEMS -inducedreasoned Top2 hypomorphic allelesl mutasions weuld preasoned useful resource that would complement thypomorphicop2 P-element insertion andeles (Bloominulln Stock Center).

Unexpectedly, the present study and previous reports indicate that both hypomorphic and hypermorphic expression of the NRG1 gene may produce several common behavioral phenotypes in mice.

A caveat is that the single base changes induced by ENU are well-known to cause both hypomorphic and neomorphic alleles.

We introduced aPKC null, zygotic mutations into both armF1a, GSK3 (hypomorphic arm and null GSK3 both maternal and zygotic mutants) and armF1a mutants.