Sentence examples for both histone types at from inspiring English sources
Such results have important implications for the evolutionary constraints affecting both histone types at the nucleotide level.
A fifth histone type (H1/H5) helps this folding by interacting with DNA at the entry-exit of each nucleosome [3].
Interestingly, both histone H3 dimethylated at position 79 (H3K79me2) and histone H3 trimethylated at position 79 (H3K79me3) were highly dynamically and similarly distributed in male germ cells (Fig. 1A,B, respectively, column 1, asterisk; column 3, arrow; column 4, arrowhead).
Thus, both histone synthesis/deposition and histone degradation/eviction must occur at approximately equal rates to maintain steady state DNA-bound histone levels and nucleosomal and genomic stability.
During cell activation and active transcription, both histone methylation and histone acetylation are present at the promoter and enhancer levels, potentiating gene transcription.
In this study, we demonstrate that PLZF is deacetylated by both histone deacetylase 3 and the NAD+ dependent deacetylase silent mating type information regulation 2 homolog 1 (SIRT1).
By ChIP-qPCR, we found that both histone marks are increased in the de-repressed state at the FSHD locus.
SIRT1 recruits and activates histone methyltransferase (HMT) at the target sites and therefore regulates both histone acetylation and methylation.
CBP and p300 are not only transcriptional co-activators but also histone acetyl-transferases (HAT) that acetylate both histone and non-histone proteins (Fig. 3) [99, 100].
Similar to histone acetylation, histone methylation is dynamically regulated by both histone methyltransferases (HMTs) and histone lysine demethylases (HDMTs).
