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DHA and AA are both highly enriched in neural tissue while DHA is the major component of retinal photoreceptor membranes [74] [76].
We also found that a precursor of neurotensin/neuromedin N (NTS), as well as UTS2B, a peptide with potent vasoconstrictor activity, are both highly enriched in HVC and could represent novel peptides used by HVC neurons themselves.
The binding sites for paired box gene 6 (PAX-6) and BRN-2 were both highly enriched in cluster 2 genes.
MIR3 and MIRb (which are both highly enriched in our E2T dataset) share a common core of 70 bps which is strongly conserved in human and mouse [ 28, 61].
We undertook further study of Nrg4, as it was both highly enriched in BAT vs. WAT and upregulated in WAT following cold exposure and seemed likely to be an important novel signaling factor in adipose tissue that could have a key role in adipocyte-neuronal cross-talk.
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Since both regions are highly enriched in 'A's, we expected, and observed, an enrichment in terms of GRO-seq reads at both termini of the coding region (Fig. 4E).
Early and late responding genes, whether up- or down-regulated and at all concentrations of both inhibitors, were highly enriched in genes involved in transcriptional regulation.
Bioinformatics analysis of the yeast and human spliceosomes revealed that despite the fact that the sequence homology between the yeast and human spliceosomal proteins ranges from 36% to a little over 50%, the spliceosomal proteins of both species are highly enriched in intrinsic disorder.
In An. gambiae, it has two genes coding for gSG7 and gSG72, both of which are highly enriched in female SGs [ 13].
The red and blue modules showed similarly high correlations with genotype (0.54, P < 0.0005; 0.49, P < 0.001, respectively) but while synaptic genes were included in both, they were more highly enriched in the blue module.
Finally we followed all 778 probes that mapped to Gene Ontology (GO) annotations "GO 0055114 ~ oxidation reduction" and all 361 probes that mapped to "GO 0009611 ~ response to wounding", both of which were highly enriched in the transcript cluster.
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