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Only at the lowest dose of 3.1 mg/kg and not at both higher doses of 9 and 18 mg/kg, obidoxime showed significant reactivation in the medulla oblongata, but not in blood or other brain parts.
In contrast, the clinical remission rate in patients who required IFX intensification was 93.3% at week 52; of the latter, 47.0% had received IFX-dose escalation, 11.8% received IFX infusions at shorter intervals, and 41.2% received both higher doses of IFX and doses at shortened intervals.
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These data suggested that differences between studies in remission rates of UC patients receiving IFX intensification may be because of differences in the percentage of UC patients who received both higher dose of IFX and doses at shortened intervals.
On the contrary, both high doses of doxorubicin and nutlin-3a promoted quiescence, a reversible cell cycle arrest that can be overcome upon the removal of the triggering stimulus.
In vitro studies have demonstrated that the apoptosis of mouse autoreactive immature T lymphocytes requires both high doses of adenosine produced by macrophages and adenosine A2 receptors expressed in immature lymphoid cells.
As shown in our results, both high dose of NMDA and co-application of low doses of NMDA and dopamine induced GluR1 withdrawal from the synaptosomal fraction (Fig. 7), suggesting for a resemblance also in the molecular mechanisms involved for this synaptic depression.
Both low and higher doses of MET augmented the antiproliferative effects of both 2 and 8 Gy IR, and statistical analysis of the interaction indicated synergy between the two treatments (see Results and Supplementary Table S1).
Both the lower and higher doses of carvedilol were effective in decreasing the rate of apoptosis (approximately a 58% reduction).
The reduced levels of testicular DNA were significantly attenuated by both the medium and higher doses of lutein (80 and 160 mg/kg), while only the higher dose of lutein (160 mg/kg/day) brought back RNA levels to its normal values (Fig. 5).
Both were subsequently exposed to higher doses of hydrogen peroxide.
Very-low-protein diets (vLPDs: 0.3 g/kg/day) combine both approaches and usually require higher doses of supplements.
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