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As PDRICG is dependent from both hepatocellular function and effective sinusoidal perfusion, this consecutively leads to reduced PDRICG.
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Two possible explanations for this observation might be that either PDRICG does not reflect liver function at all or PDRICG gives additional information on hepatocellular function and hepatosplanchnic perfusion that is not 'detected' by the classic liver function tests.
More data are required to investigate this interesting observation of a survival benefit from simvastatin in this situation, which may relate to its effects on hepatocellular function, fibrosis and portal pressure.
Hepatic blood flow and hepatocellular function are altered, and consequently, hepatic clearance of morphine can be impaired [ 39].
Other endpoints included hospitalisation-free survival, hepatocellular function, clinical benefit and alpha-FP kinetic.
Exercise-induced muscle inflammatory response is less severe in women than in men, female rodents have improved hepatocellular function following trauma, and also improved survival in sepsis.
In this study, we demonstrated that PDRICG is not correlated with classic liver laboratory tests; hence, it may provide additional information on hepatic blood flow and hepatocellular function.
The two features combine to cause portal hypertension and reduced hepatocellular function.
Current techniques that maintain hepatocellular function in vitro with different biomaterials and geometries exhibit a low cell density and functional capacity per unit volume.
Many lympho- and monokines may alter hepatocellular function.
Thus, we can correlate increased amino acid uptake rates and changes in glucose metabolism to hepatocellular function at the stable stage of culture.
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