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In the majority of patients in both groups with significant creatinine increases, the impairment in renal function had resolved or was resolving at the last follow-up visit.
Lactate levels were slightly elevated at Tbsl in both groups, with significant increase in the SVI-group, which reduced by T4.
In the APOLLO trial, the quality-of-life assessment improved in both groups with significant (P < 0.0001) advantage of basal insulin treatment over the prandial regimen, using a different quality-of-life assessment score (21).
Somatic symptoms changed in a non-linear pattern for both groups, with significant decreases from baseline to 10-year follow-up and significant increases from the 10-year to the 23-year follow-up.
Measurements of vWF-concentrations showed rising trends uniformly for both groups with significant higher values at 1 hour after CPB initiation for IWC-group compared to the ICC-group (ICC: 178.4 ± 73.2 U/dL; IWC: 258.2 ± 89.7 U/dL; P < 0.001; Figure 4).
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Significant recovery in physical performance and health status was seen after discharge in both groups, with no significant difference between groups at one year.
Overall outcome (primary and secondary) was comparable across both groups with no significant difference.
Over time sNa decreased significantly with 4 mmol/l in both groups, with no significant difference between groups.
Condition-specific quality of life and bleeding scores were significantly improved from baseline at 6 months in both groups with no significant differences between them (Table 3).
Renal function was similarly impaired in both groups, with no significant difference in creatinine and BUN plasma concentrations, inulin and creatinine clearance (Table 2), as well as RIFLE score distribution (Fig. 3).
Analyzing the two samples throughout the observation period (T0-T2), we found that correction of molar relationship occurred in both groups with no significant differences in terms of sagittal and vertical skeletal changes.
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