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As a result of vaccination, both groups were assumed to become immune against both disease and infection (Figure 1).
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Dropouts in both groups are assumed to be missing at random.
In our study, proportional hazards for both groups are assumed, as there is no difference in management policy for each group.
PFS at 15 months in both groups was assumed to be 38%, and the low non-inferiority limit was set as −13%, corresponding to a HR of 1.43.
The population standard deviation used is 18.5 [ 32] and the Pearson correlation coefficient between the pre and post scores for both groups is assumed to be 0.7, based on pilot data available from the University of Melbourne.
The difference between the mean scores of both groups was assumed to exceed the minimal clinical important difference (MCID) of 10 DEMMI points reported for the Australian English DEMMI version [ 20].
If the two groups of haplotypes that carried the B allele were not significantly different from each other but were significantly different from the group of haplotypes that carried the A allele, both B haplotypes groups were assumed to carry the favorable allele of the causative mutation.
The presence of two types of binding sites in humic acid, carboxylic and phenolic functional groups, were assumed at both low and high pH conditions.
Thus, the covariance matrices between the education groups were assumed to be equal for the purposes of the MANOVA.
The supplementation and control groups were assumed to be comparable with regard to these indices.
The standard deviations of the control and experimental groups were assumed to be equal for all simulations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com