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In both groups, the hypertonic saline induced a significant reduction.
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Compared with the control group and the normal saline group, the hypertonic dialysate group showed significantly reduced UF capacity and glucose reabsorption (D2/D0) while increased dialysate-to-plasma urea ratio (D/Purea) (all P <0.05) (Table 1).
U-AQP2 increased in both groups after hypertonic saline.
U-osm increased significantly in both groups during 3% hypertonic saline, but to a higher extent in controls than in patients { mean difference at 240 min patients: 289 ± 155% vs. mean difference controls: 125 ± 141%), p = 0.001}.
From 120 to 210 minutes, the increase in MPAP was significantly more important in the NC group compared with the hypertonic groups.
P-Osm increased to the same extent in both groups in response to hypertonic saline infusion.
In contrast, expression of α-SMA and COL-1 were both up-regulated in the hypertonic dialysate group (all P <0.05).
Compared with the control and the saline groups, hypertonic dialysate group showed impaired peritoneal function accompanied by a spectrum of morphological changes including thicker peritoneal membrane, higher collagen deposition, infiltration of mononuclear cells and neovascularization in the peritoneum.
P-AVP increased significantly in both groups and to the same extent in response to hypertonic saline infusion, with a maximum at 150 min and a uniform steady reduction during the post infusion period.
Compared to the hypertonic groups, this EO2 increase was significantly more important in the NC group from 210 to 300 minutes.
Contrarily, these variables levels increased over time in the hypertonic groups (P <0.001 at 300 minutes) without any differences between the HSB and HSL groups.
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