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After CTX injury, however, the genotype of the BM donor determined the histological appearance of the muscle; that is, both groups of host mice receiving WT BM had a similar histological appearance, whereas both groups of host mice receiving CCR2−/− BM were comparable.
In both groups of host mice receiving WT BM (WT→WT and WT→ CCR2−/−) macrophage accumulation was similarly robust and significantly (P<0.001) increased compared with both groups of host mice receiving CCR2−/− BM at both 3 and 7 days after CTX injury.
In both groups of host mice receiving WT BM (WT→WT and WT→ CCR2−/−), fiber size was comparable and significantly (P<0.001) greater than that of host mice receiving CCR2−/− BM.
Tissue macrophages were significantly (P≤0.03) increased at day 3 compared with day 7 in both groups of host mice receiving WT BM but were similar in both groups of mice receiving CCR2−/− BM (Table 4).
Perhaps more important, numbers of MPCs were significantly increased in host mice receiving CCR2−/− BM compared with host mice receiving WT BM at both day 3 (P≤0.02) and day 7 (P≤0.005) after injury; this finding was surprising given the subsequent reduced size of regenerated myofibers in both groups of host mice receiving CCR2−/− BM (Table 2).
Numbers of MPCs (CD34+/Sca-1−/CD45−) injuredred muscle were determined in the chimeric groups at days 3 and 7 after CTX injection by flow cytometry (Fig. 4 B, C ). Numbers of MPCs were significantly (P≤0.006) increased at day 7 compared with day 3 in both groups of host mice receiving CCR2−/− BM but not in host mice receiving WT BM (Table 4).
Similar(54)
Research so far has concentrated mainly on individual genes or small defined groups of host or PDV genes, to explore their function or differential expression following parasitization.
The mean survival of groups of host mice bearing EA/DR treated with 5 mg kg-1 or 10 mg kg-1 CsA simultaneously with daunorubicin for five days was also greater than 60 days.
The presence of related lice on related groups of hosts may evidence parallel evolution of parasites and hosts.
Commonly, for example, virulence of an infective agent is determined experimentally by inoculating groups of hosts with graded doses of the agent and determining, by interpolation, the dose that produces a typical reaction in 50percentt of the host individuals inoculated.
By creating logical groups of hosts based on department or even physical location, one can effectively approach scanning larger networks by section instead of trying to scan and deal with data from a mass scan.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com