44 An SNP barcode could permit tracking multi-locus genotypes in time and space provided the local transmission dynamics or history yield stable SNPs.
We now hope to extend a detailed molecular epidemiological study on the M. tuberculosis isolates from the 3 French departments isolated in 2006 2012 so as to see the evolution of above mentioned genotypes in time and space.
From 45 to 90 dai, TcPR-4b was superexpressed in both genotypes in comparison to the control (about 8 times more at 60 and 90 dai).
GSK3 knockin mice spent similar times as wild-type mice in each chamber, with both genotypes spending more time in Chamber 1 containing the S1 mouse than in Chamber 3 containing only the wire enclosure (Fig. 4B, WT: F 2, 45) = 117.29, P<0.001, GSK3 knockin: F 2, 45) = 117.29, P<0.001).
At least one transcript related to Cdc2 was found to accumulate in both directions for both genotypes over time (see Additional files 4 and 5).
Rapid nuclear localisation of β-catenin also occurred in the aberrant areas in both genotypes and the time scale for loss of differentiation status of enteroendocrine cells (assessed by Grimelius staining) and Paneth and goblet cell mislocalisation (assessed using anti-Lysozyme IHC and alcian blue staining respectively) was identical in both genotypes.
Firstly, coordinated increases in levels of most AAs occurred in both genotypes at most time points during the chilling stress with the most dramatic increase synchronized the maximum difference in CT between LTH and IR29 during the chilling stress.
During endotoxemia, mean arterial blood pressure (MAP) decreased in both genotypes, with the time course of sepsis-induced hypotension being markedly accelerated in Arap1-/ compared to +/+ mice.
Interestingly, the maximum number (13) of the 15 measured AAs showing significant increased level occurred at 8h and 24 h time points of the chilling stress, though none of the 15 AAs had significantly increased levels in both genotypes at all time points of the stress except for threonine, isoleucine and valine.
Six sugars (glucopyranose, glucose-6-p, sucrose, lactose, mannitose, trehalose, 3-p-glycerol and sorbitol-6-p) showed consistently reduced levels in both genotypes at all time points of the stress.
