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Furthermore, undifferentiated thyroid carcinomas have been shown to be S100A8/9 immunopositive and both genes were associated with, e.g., inflammation-associated cancer and aggressive breast cancer [41, 53, 54].
Variants in both genes were associated with nearly equal protection from cardiovascular events such as heart attacks, and this effect seemed to be additive.
We also observed linkage to the region containing the IL1 complex of genes, with TB as the phenotype; IL1B has been associated with TB in Japanese [34], Gambian [35] and Columbian [36] study populations, while IL1RA has also been associated with TB in a Gambian population [37]; both genes were associated with pleural TB in a Gujarati Hindu population in England [38].
Both genes were associated with SDV (Table S13).
After tolerance and toxicity analysis, both genes were associated with the same 16 drugs (one of them being disulfiram; see Additional file 1: Table S5).
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Both genes are associated with response to double-strand DNA breaks and apoptosis induction.
Since SYNE1 polymorphisms have been previously associated with estrogen related events, an expression link between the pro-inflammatory cytokine TNF with SYNE1 in cases might explain why polymorphisms in both genes are associated with MM in our population.
Both Pten and Lkb1 play fundamental roles in regulating this pathway, and mutations of both genes are associated with neoplasia.
In fact, a common biological pathway for NCX1 and NCKX3 is shown as both genes are associated with the same phenotypic trait (variation in SBP after salt load) and display an epistatic interaction that affects PNat120.
Both genes are associated with attention in schizophrenia [ 36].
Both genes are associated with various inflammatory processes including Alzheimer's disease [ 25].
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