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Expression levels of repat5 and arylphorin also showed a strong correlation, suggesting that both genes may be part of the same biological process.
Therefore, these data appear to indicate that whilst both genes may be involved in resistance to these drugs, the ATN + MF resistance phenotype is more complex and is likely to involve mutation(s) in other gene(s).
However, if the interaction of two genes is important, only triplets containing both genes may be wanted.
Finally, NGS-based testing of all coding exons in both genes may be reserved for patients with breast or ovarian cancer that is more likely related to BRCA.
Both genes may be functionally essential to maintain Buchnera – making the nuclear inserted copy a strong candidate for being functionally active, with the product targeted to the endosymbiont.
One gene may be lost relatively rapidly, or both genes may be retained and diverge functionally, either by sub-specialization of the original function or by evolving new functions [ 62, 63].
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Whether alterations in both these genes may be able to confer a more aggressive phenotype remains to be established in larger series.
According to the present study, it could be assumed that both PE_PGRS genes may be dispensable for normal in vivo growth under certain conditions as they are absent from the genome of M. leprae, and PE_PGRS18 was frame-shifted in the two " M. canettii" and two other smooth tubercle bacilli strains analysed.
As Cb-egl-5 and Cb-mab-5 are closely linked, variation in either or both of these genes may be responsible for the observed association.
These findings support the hypothesis that abnormalities of both tumor suppressor genes may be involved in the pathogensis of gastric cancer, and the p53 damage may precede an abolished DCC function.
Given that two Octomom genes with possible regulatory (the helix-turn-helix-containing gene WD0508) or effector (the ANK-containing gene WD0514) function are relatively weakly expressed in the nonpathogenic wMel variant, it is possible that overexpression of one or both of these genes may be responsible for the pathogenic phenotype when Octomom is amplified in wMelPop (Chrostek and Teixeira 2015).
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