In both approaches, genes implicated in oligodendrocyte structure and function were downregulated, whereas genes associated with neuronal enrichment were upregulated.
Both strongly express genes implicated in the maintenance of pluripotency, self-renewal, genome surveillance, and cell fate determination in pluripotent stem cells (Sperger et al., 2003; Abeyta et al., 2004; Byrne et al., 2006).
The 14 commonly altered genes by all PPAR agonists in both cell models included genes implicated in lipid metabolism (CD36, PLIN4, ADFP, ANGPTL4) and oxidative stress (POR, HMOX1).
An analysis of metabolic pathways using the Kyoto Encyclopaedia of Genes and Genomes (KEGG; see Additional file 1) showed that, generally, genes from similar pathways were identified from both ORESTES and SSH, for instance, genes implicated in the immune system showed similar numbers in each pathway from both techniques.
This study provides further evidence that lung cancer results from the combined effects of several genetic variants [83] with low penetrance [84] from genes implicated in both COPD and lung cancer [26] [28].
Expression profiling reveals global changes in the expression of genes implicated in both myofiber phenotype and metabolic functions.
Genome-wide association studies (GWAS) and next-generation sequencing (NGS) are performed routinely to identify genetic variants and novel genes implicated in both common and rare human diseases.
Both unsupervised and supervised gene expression analysis identified simple classifiers (harboring both smoking induced genes and genes implicated in lung tumorigenesis) with high sensitivity in identifying never-smokers across multiple AC and normal tissue data sets.
Within this data set we observe genes implicated in both dilated and familial cardiomyopathy as well as genes associated with oxidative phosphorylation deficiencies and biochemical disorders of amino acid metabolism.
Light pulses (both short and long) also regulated genes implicated in feeding as well as different physiological processes like metabolism, transport, immunity and protease digestions.
