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Both genes are implicated in S motility [ 118] and in efflux of heavy metal ions [ 91].
However, the introduction of P27 or P55 alone did not complement the wild type level of resistance (Table 3), indicating that both genes are implicated in this mechanism.
As both genes are implicated in NF-κB (nuclear factor κB) signalling, we measured p65 activity and TNFα (tumour necrosis factor α) levels 24 h after MCAO.
As shown in Supplementary Material, Figure S8, both genes are implicated in formation of platelets thereby providing a clear link to the GWAS-trait 'platelet count'.
Interestingly, in six out of the eight most negatively correlated pairs of genes, one or both genes are implicated in a regulatory function.
Indeed, taking into account that during early somitogenesis, the endoderm patterning initially requires suppression of the canonical Wnt signalling, while later an increased Wnt/beta activity is necessary [ 37], we understand that both genes are implicated in the regulation of the canonical and non canonical Wnt signalling pathways.
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As both of these genes are implicated in the development and function of the mammalian brain, these results have relevance to human health as well as to understanding more general biological processes.
As both of these genes are implicated in oncogenesis, it is conceivable that loss of p16 or gain of COX-2 expression may make these cells more susceptible to transformation, although it is unclear whether the loss of p16 and gain of COX-2 occur de novo during self-selection or represent selection of a minor population of cells with pre-existing high COX-2 and low p16 expression.
In this panel, 50 genes are shown to be associated with non-syndromic OFCs, 58 are involved in the pathogenesis of syndromes whose features include OFCs, and 18 genes are implicated in both cases.
We know that certain genes are implicated in certain types of cancer, which is why family history has a lot to do with your individual risk.
And many of these genes are implicated in cancer.
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both genes are arranged
both genes are imprinted
both hormones are implicated
both genes are linked
both genes are coded
both cytokines are implicated
both genes are known
both proteins are implicated
both genes are driven
both regions are implicated
both genes are regulated
both genes are induced
both genes are controlled
both areas are implicated
both enzymes are implicated
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