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A further factor which limits both generalizability and replication of this study is the dynamic and responsive nature of discussions between the authors, as facilitators, and the participants in each focus group session.
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There is an emerging need to strike a balance between simplicity and detail in order to ensure both generalizability and accuracy of predictions.
Despite the strengths of this study, there are several limitations that challenge both the generalizability and validity of the findings.
Yet, they do not simultaneously accommodate for both isolation and replication.
40345_2017_101_MOESM1_ESM.docx Additional file 1. Detailed prediction results in both discovery and replication cohorts.
Both structural and replication genes are not clustered in CP21.
The remarkable conservation of the properties of the social vulnerability index approach and associations (albeit of two indices differing in the details of their construction but sharing a common approach and theoretical basis) with health in two different cohorts of older Canadians suggests generalizability and reproducibility, though replication in other populations and settings is needed.
The fact that both case and control participants were sampled from a single general hospital in an urban district of Taipei may limit generalizability and findings require replication in other settings.
Thus, the external validation remains the only way to determine both the generalizability and the true predictive ability of QSAR models for new chemicals.
Thus, the external validation regards the only way to determine both the generalizability and the true predictive power of QSAR models for new chemicals.
Rif1 loss affects both number and replication-timing specificity of the interactions between replication-timing domains.
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