We then mapped both gene expression patterns and fate maps onto the same reference wing bud models and, using computational methods, determined the transcription factor genes expressed by the cells that give rise to the different digits.
We suggest that the use of either of these two computational models to study the evolution of a gene's expression may be subject to great uncertainty, and the investigation of changes in both gene expression patterns over corresponding tissues and co-expression of the gene with other genes is necessary.
Moreover, we have shown that both gene expression patterns are characterized by opposite profiles in reproductive tissues across species.
It has become evident through microarray-based studies that BC with genomic amplification of HER2 (HER2-amplified) constitutes a biologically heterogeneous subgroup of tumors regarding both gene expression patterns and copy number alterations (CNAs) [ 4, 5].
The recent development of DNA microarrays has enabled an unprecedented level of genome-scale research on both gene expression patterns [ 42, 43], and also on genomic DNA copy number changes and genome rearrangements through the "array-CGH" ("aCGH") technique [ 44, 45], which we will refer to as "microarray karyotyping" or "array karyotyping".
GEM-TREND provides both gene-expression pattern-based and text-based searches to retrieve gene expression data from GEO.
For a GEO gene expression data search, both gene-expression pattern-based searches (either gene-expression signatures or gene expression ratio data as inputs) and text-based searches (accepting keywords, platform IDs, or series IDs as inputs) are available, but similarity scores and p-values are calculated only for gene-expression pattern-based searches.
To limit the effect of enviromental influences on gene expression pattern, both pigs were housed and fed with the same conditions and were prepubescent at slaughter time.
The functional consequences of this were investigated by co-culture experiments revealing that the co-incubation of stromal cells with B cell progenitors altered both the morphology and the gene expression pattern in the stromal cells.
Before examining leptin effects, we investigated the baseline gene expression pattern in both groups.
The correlation of fold changes in gene expression between the arrays and PCR is shown in Figure 2. The results demonstrate a consistent gene expression pattern between both methods.
