Sentence examples for both gene conversion and from inspiring English sources
Notably, single aa substitutions in the 4-aa linker affected the ZFN activity significantly, and both gene conversion and ZFN-associated toxicity depended on the linker/spacer combination and the cell type.
In DT40-SWΔC cells, both gene conversion and point mutation occurred in the IgV gene with over threefold higher frequency than in DT40-SW cells, suggesting that a lower level of the mutant AID protein was sufficient to increase mutation frequency.
Both gene conversion and unequal crossing over have occurred during the evolution of the KRTAP.
Indeed, both gene conversion and gene duplication have shaped the evolution of the IFN-α gene family in eutherian species [ 19].
It potentially detects both gene conversion and unequal recombination events (two mechanisms to generate concerted evolution) but can not distinguish between the two phenomena.
Conversely, there is some evidence indicating that the regions undergoing concerted evolution have lower dN/dS values, suggesting that both gene conversion and purifying selection are acting at these sites.
Whereas srs2 Δ shows increased levels of gene conversion events, the elg1 Δ mutant shows both high gene conversion and high DRR levels.
They concluded that Brca1-/-cells had a consistently fivefold to sixfold lower level of homologous recombination by both noncrossover gene conversion and deletion.
To assess the specific number and positions of both meiotic gene conversion and crossover events, we sequenced the genomes of male progeny from females heterozygous for 93,538 X chromosomal single-nucleotide and InDel polymorphisms.
Murine fibroblasts with the same null mutations employed here have been reported to show reduced DSB repair by both homology-directed gene conversion and SSA with an accompanying increase in repair by error-prone NHEJ [17].
Subsequently, we performed simulations with both crossing over and gene conversion and attempted to jointly estimate both γ and ρ for these data sets with the mean tract length set to its true value.
