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Both functional and sequence conservation patterns found among species further support the CSA:Drought detection of cross-species DEGs.
Interestingly, enhancers of developmental regulatory genes are among those with the greatest amount of both functional and sequence conservation between mouse and human [ 16].
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In practice, experiments make use of a combination of both functional and sequence-based approaches based upon the function of interest, the complexity of the sample to be screened, and other factors.
Of those, 723 nine nt sequences are both functional and non-functional in different sequences.
However, promoter sequences contain both functional and non-functional binding sites.
These experiments 41 demonstrated that FCRL5's cytoplasmic ITIM and ITAM-like sequences are both functional and that the receptor has counter-regulatory properties.
Remarkably, in some vertebrate mtDNA genomes where the non-coding control region has been duplicated, both copies appear functional and extreme sequence similarity between the copies suggests that the two control regions are evolving in concert (e.g., [ 7]).
While the current catfish microarray is limited by the large number of "unknown" candidate sequences, both functional experimentation and comparative genomic analyses should help improve and identification of the large number of catfish ESTs currently without annotation.
This is a useful tool in both functional genomics and the annotation of genome sequences, but also can also provide a potentially stand-alone resource in the face of difficult genomes where whole genome sequencing is problematic.
Moreover, the existence of both beneficial functional amyloid sequences, and putatively pathogenic 'misfolded' amyloid proteins suggests a more complicated sequence/structure relationship than is found in standard protein folding models.
Anoctamin protein sequences were scanned for the presence of protein domains and functional sequence patterns with InterProScan and SMART servers.
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