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In this paper we analyze a set of eukaryotic transcription factor binding sites and show that there is extensive clustering of similar k-mers in eukaryotic motifs, owing to both functional and evolutionary constraints.
In summary, the whole-genome sequencing of 12 species of Drosophila has elucidated both functional and evolutionary patterns of fundamental importance.
Most of such duplications, in Xanthomonas, seem to have arisen from old events and possibly enlarge both functional and evolutionary genome potentiality.
Databases of expressed sequence tags (ESTs) are available for a number of plant species and represent invaluable resource for both functional and evolutionary studies, providing information on both genetic diversity and expression profiles.
Indeed, recent evidence increasingly supports both functional and evolutionary relationships between the organelles served by these complexes, the nuclear envelope/ER and vacuole, with proteins such as Rab32 (Sandoval and Simmen 2012), Syntaxin 17 (Itakura et al. 2012; Hamasaki et al. 2013), and PACS-2 (Simmen et al. 2005; Atkins et al. 2008) appearing to function in both locations.
A detailed examination of the medaka Egfr/Egfr ligand system, considering both functional and evolutionary aspects, revealed that the medaka genome contains two Egfr gene copies, namely egfra and egfrb, but only one copy of each of the seven Egfr ligand genes.
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In both cases, functional and evolutionary consequences can be derived from that structural information.
All these provided us the opportunity to investigate both the functional and evolutionary characteristics of the cytochrome P450 genes in T. thermophila at the genomic level.
In the coming years, it will be interesting and exciting to uncover the mechanisms that regulate sexual dimorphism downstream of the sex hierarchy in both a functional and evolutionary context.
In particular, the Tetrahymena Genome Database (TGD, http://www.ciliate.org) and Tetrahymena genome expression database (TGED, http://tged.ihb.ac.cn) [ 28, 29] provide the opportunity for analysis of both the functional and evolutionary characteristics of gene families at the genomic level in this model organism [ 30].
They believe that similar domain compositions inside the neighbors may indicate both functional similarity and evolutionary relationship, and define a domain context similarity to assess the function similarities between proteins.
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both functional and dysfunctional
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both stationary and evolutionary
both structural and evolutionary
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